Hydrazinolyse de la 2-Benzoyl-3-oxo-1,4-benzothiazine
The hydroxypyrazole derivatives 2 and 3 have been synthesized by hydrazinolysis of 2-benzoyl-3-oxo-1,4-benzothiazine 1 by ring transformation of the thiazine ring. The mechanism of the hydrazinolysis is described. Products 2 and 3 have been characterized by IR, 1H and, 13C NMR spectroscopy, as well as by mass spectrometry. The crystal structure of 4-[(2-aminophenyl)sulfanyl]-5-hydoxy-3-phenyl-1H-pyrazole 2 has been determined. The compound crystallizes monoclinic in the space group P21/n with two ethanol molecules in the formula unit.
Keywords: Benzothiazine; crystal structure; hydrazinolysis; pyrazole
Document Type: Research Article
Affiliations: 1: Laboratoire de Chimie Organique et Etudes Physicochimiques, ENS, Rabat, Maroc 2: Laboratoire de Chimie Organique Heterocyclique, Universite Mohammed V, Rabat, Maroc 3: Laboratoire de Biochimie, FST, Mohammedia, Maroc 4: Pharmacochimie, Universite Victor Segalen Bordeaux II, France 5: Institut de Chimie Organique et Analytique, Universite d'Orleans, France
Publication date: 01 August 2008
- Access Key
- Free content
- Partial Free content
- New content
- Open access content
- Partial Open access content
- Subscribed content
- Partial Subscribed content
- Free trial content