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Home / Phosphorus, Sulfur, and Silicon and the Related Elements, Volume 182, Number 12

Preparation of 2,3,4-Trihydroxybutylarsonic Acid: A Starting Compound for Novel Arsonolipids

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Possible routes for the preparation of 2,3,4-trihydroxybutylarsonic acid, a key compound for the synthesis of novel arsonolipids, were experimentally evaluated. The best substrate was found to be 3,4-epoxybutane-1,2-diol. Its reaction with alkaline sodium arsenite, "Na3AsO3," gave the arsonic acid in ∼ 50% yield, as two pairs of diastereoisomers, each pair being a racemic mixture.

Keywords: 1,3-butadiene diepoxide; 2,3,4-Trihydroxybutylarsonic acids; 3,4-butene-1,2-diol; 3,4-epoxy-1-butene; 3,4-epoxybutane-1,2-diol; chloramine T; trichloroisocyanuric acid

Document Type: Research Article

Affiliations: Department of Chemistry, University of Patras, Patras, Greece

Publication date: 01 December 2007

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