Utilization of Methyl 3-Aryl-2-thiocyanatopropanoates in the Synthesis of 2-(4-Morpholinyl)- and 2-(Piperazinyl)-5-(benzyl)thiazol-4-ones1
By the reaction of methyl acrylate with arenediazonium salts and KSCN in the presence of copper(II) acetate, the methyl 3-aryl-2-thiocyanatopropanoates 2 have been obtained. These compounds react with morpholine or monosubstituted piperazines in the presence of acetic acid to form 2-(4-morpholinyl)- or 2-(4-R-piperazinyl)-5-(R' -benzyl)thiazol-4-ones 4 and 5, respectively.
Keywords: Arylation; Thiazol-4-ones; cyclization; piperazines; thiocyanates
Document Type: Research Article
Affiliations: Department of Organic Chemistry, Ivan Franko National University of Lviv, Lviv, Ukraine
Publication date: 01 July 2007
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