A New and Efficient Method for the Protection of Alcohols and Phenols by Using Hexamethyldisilazane in the Presence of Anhydrous Ferric Chloride under Mild Reaction Conditions

Author: Akhlaghinia, Batool

Source: Phosphorus, Sulfur, and Silicon and the Related Elements, Volume 182, Number 3, March 2007 , pp. 687-694(8)

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Abstract:

Alcohols and phenols are protected with hexamethyldisilazane in the presence of anhydrous ferric chloride in good to excellent yields in acetonitrile. This method is highly selective for the conversion of primary alcohols in the presence of secondary and tertiary alcohols and also for conversion phenols.

Keywords: Alcohol; ferric chloride; hexamethyldisilazane HMDS; phenol; trimethylsilylether

Document Type: Research article

DOI: http://dx.doi.org/10.1080/10426500601047487

Affiliations: 1: Department of Chemistry, Damghan University of Basic Sciences, Damghan, Iran

Publication date: 2007-03-01