Cyclosulfamides as Constraint Dipeptides: The Synthesis and Structure of Chiral Substituted 1,2,5-Thiadiazolidine 1,1-Dioxides: Evaluation of the Toxicity
A general synthesis for the preparation of chiral N - N ′ substituted 1,2,5-thiadiazolidine 1,1-dioxides has been developed beginning with proteogenic amino acid, sulfuryl chloride, and dibromoethane. The selected chemistry and spectral properties of these compounds are examined. Overall, routes described are applicable to the synthesis of a variety of constrained dipeptidal sulfamides representing novel peptidomimetic scaffolds.
Keywords: Amino acids; constraints peptides; cyclic sulfamides
Document Type: Research Article
Affiliations: Laboratoire de Chimie Organique Appliquée, Groupe de Chimie Bioorganique, Faculté des Sciences, Département de Chimie, Université d'Annaba, Algérie
Publication date: 01 June 2006
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