Solid Acid Induced Cyclocondensation: A Facile, One-Pot Synthesis of 7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines
7H-[1,2,4]Triazolo[3,4-b][1,3,4]thiadiazines are synthesized in good yields by the catalytic action of sulfuric acid adsorbed on sillica gel. Starting from 4-amino-5-substituted-1,2,4-triazole-3-thiones and employing cyclocondensation reaction with α-chloroacetonitrile and α-haloketones, the desired triazolothiadiazines have been synthesized satisfactorilly.
Keywords: cyclocondensation; solid acid; triazolothiadiazine; α-Haloketones
Document Type: Research Article
Affiliations: 1: Department of Chemistry, School of Sciences, Azzahra University, Vanak, Tehran, Iran 2: Department of Chemistry, School of Sciences, Ferdowsi University, Mashhad, Iran
Publication date: 01 October 2002
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