PHOTOCHEMICAL SYNTHESIS OF CHRYSENOLS
Chrysenols are formed together with other metabolites when chrysene is metabolized in living organisms. The principal metabolites are needed as pure compounds for reference materials and standards to study various aspects of this metabolism. In this study the 1-, 2-, 3-, and 4-chrysenols
have been made in pure form by photochemical ring closure of [(methoxyphenyl)vinyl]naphthalene to the methoxychrysenes followed by deprotection, and purification of the chrysenols. The method may be applied to make the single pure compounds in high yields.
Keywords: Photocyclization; chrysenol; hydroxychrysene; metabolites; synthesis
Document Type: Research Article
Affiliations: Faculty of Science and Technology, University of Stavanger, Stavanger, Norway
Publication date: 01 August 2008
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