In vitro antitumor activity of triterpenes from Ceriops tagal

Authors: He, Lei; Wang, You-Shao; Wang, Qing-Ji

Source: Natural Product Research, Volume 21, Number 14, December 2007 , pp. 1228-1233(6)

Buy & download fulltext article:

Price: $56.94 plus tax (Refund Policy)

Abstract:

The embryo of Ceriops tagal was extracted with 95% ethanol at room temperature, and four triterpenes (1-4) were separated from this extract. For the first time these triterpenes were the separated from this plant. Compounds (1-4) were tested in vitro for antitumor activity against three cell lines (human liver cancer cell (H-7402), human B-lymphoblastoid cell (Raji), and human cervical carcinoma cell (Hela)). Compounds 1 and 3 were effective to inhibit cell proliferation and growth of H-7402 and Hela, the IC50 of them on H-7402 were 14.42 µg mL-1 and 9.97 µg mL-1, and the IC50 of them on Hela were 11.84 µg mL-1 and 11.32 µg mL-1. All compounds 1-4 were not effective to inhibit cell proliferation and growth of Raji. The effects of compound 4 on inhibiting proliferation and growth of these three cancer cells was also not obvious.

Keywords: Ceriops tagal; Rhizophoraceae; Antitumor; Triterpenes

Document Type: Research article

DOI: http://dx.doi.org/10.1080/14786410701369516

Affiliations: 1: Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academic of Sciences, Guangzhou 510301, China

Publication date: 2007-12-01