A new coumarin from the fruits of Coutarea hexandra

Authors: Olmedo, D.¹; Rodríguez, N.¹; Vásquez, Y.¹; Solís, P. N.¹; López-Pérez, J. L.²; Feliciano, A. San²; Gupta, M. P.¹

Source: Natural Product Research, Volume 21, Number 7, June 2007 , pp. 625-631(7)

Publisher: Taylor and Francis Ltd

Buy & download fulltext article:

Price: $55.77 plus tax (Refund Policy)

Abstract:

A new 5-O-β-D-glucopyranosyl-4-(4-hydroxyphenyl)-7-methoxy-2H-chromen-2-one (1), together with four known compounds, one coumarin, 5-O-β-D-galactopyranosyl-4-(4-hydroxyphenyl)-7-methoxy-2H-chromen-2-one (2) and three cucurbitacins, 23,24-dihydrocucurbitacin F (3), 23,24-dihydro-25-acetylcucurbitacin F (4) and 2-O-β-D-glucopyranosyl-23,24-dihydrocucurbitacin F (5) have been isolated and characterised from the ethanol extract of Coutarea hexandra fruits. Their structures have been established by spectroscopic analysis (NMR and MS). Interpretation of the HMQC, HMBC, COSY-45 and NOESY experiments permitted us to establish stereochemistry of the natural products. All compounds were tested in cytotoxicity assays against the breast (MCF-7), lung (H-460), and central nervous system (SF-268) human cancer cell lines.

Keywords: Coumarins; Cucurbitacins; Triterpenoids; Cytotoxicity; Coutarea hexandra; Rubiaceae

Document Type: Research article

DOI: http://dx.doi.org/10.1080/14786410701371116

Affiliations: 1: Centro de Investigaciones Farmacognósticas de la Flora Panameña (CIFLORPAN), Facultad de Farmacia, Universidad de Panamá, Panamá 0824-00172, República de Panamá 2: Departamento de Química Farmacéutica, Facultad de Farmacia, Universidad de Salamanca, Salamanca, E-37007, Spain

Publication date: 2007-06-01