Extraction of ferulic acid from Angelica sinensis with supercritical CO 2

Authors: Sun, Yongyue¹; Li, Shufen²; Song, Huiting²; Tian, Songjiang²

Source: Natural Product Research, Volume 20, Number 9, 20 July 2006 , pp. 835-841(7)

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Abstract:

Extraction of pharmacologically active ingredient of ferulic acid from the root of Angelica sinensis with supercritical CO 2 was investigated. The experimental results show that the extract yields were 0.87-4.06% at temperatures from 45 to 65°C and pressures from 30 to 50MPa, and the maximum content of ferulic aicd in the extracts was about 0.35-0.37%, which is lower than that of 0.61-0.85% by conventional percolation methods. Ethanol was used as co-solvent in different ratios to raw materials in order to increase the content of ferulic acid in the extracts. The experimental results show that both the extract yields and the content of ferulic acid in the extracts increase greatly compared with pure CO 2 extraction. When the ratio of ethanol to the raw material was 1.6, the content of ferulic acid in the extracts was 0.91-1.27%, indicating that supercritical fluid extraction (SFE) with CO 2 in the presence of suitable co-solvent is superior to percolation in extracting polar ferulic acid from Angelica sinensis .

Keywords: Extraction; Supercritical fluid; CO 2; Angelica sinensis; Ferulic acid; Co-solvent

Document Type: Research article

DOI: http://dx.doi.org/10.1080/14786410500462579

Affiliations: 1: Tianjin Municipal Institute for Drug Control, Tianjin 300070, China 2: Key Laboratory for Green Chemical Technology of State Education Ministry, School of Chemical Engineering & Technology, Tianjin University, Tianjin 300072, China

Publication date: 2006-07-20