Anti-inflammatory Furanogermacrane sesquiterpenes from Neolitsea parvigemma

Authors: Chen, Keh-Shaw1; Hsieh, Pei-Wen2; Hwang, Tsong-Long3; Chang, Fang-Rong2; Wu, Yang-Chang2

Source: Natural Product Research, Volume 19, Number 3, April 2005 , pp. 283-286(4)

Publisher: Taylor and Francis Ltd

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Abstract:

Six furanogermacrane sesquiterpenes, pseudoneolinderane ( 1 ), linderalactone ( 2 ), zeylanidine ( 3 ), zeylanicine ( 4 ), deacetylzeylanidine ( 5 ), and neolitrane ( 6 ), isolated from the stems of Neolitsea parvigemma , were tested for anti-inflammatory activities. Among them, 1 and 2 showed significant inhibitory effects on superoxide anion generation by human neutrophils in response to fMLP/CB. The IC50 of 1 and 2 were found to be 3.21 and 8.48µg/mL, respectively.

Keywords: Neolitsea parvigemma; Pseudoneolinderane; Linderalactone; Neutrophil; Anti-inflammatory

Document Type: Research article

DOI: 10.1080/14786410410001714669

Affiliations: 1: Tajen Institute of Technology, Ping Tung Hsien 907, Taiwan 2: Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan 3: Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan

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