Intraluminal thrombus and risk of rupture in patient specific abdominal aortic aneurysm - FSI modelling

Authors: Bluestein, Danny1; Dumont, Kris1; De Beule, Matthieu2; Ricotta, John3; Impellizzeri, Paul3; Verhegghe, Benedict4; Verdonck, Pascal5

Source: Computer Methods in Biomechanics and Biomedical Engineering, Volume 12, Number 1, February 2009 , pp. 73-81(9)

Publisher: Taylor and Francis Ltd

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Abstract:

Recent numerical studies of abdominal aortic aneurysm (AAA) suggest that intraluminal thrombus (ILT) may reduce the stress loading on the aneurysmal wall. Detailed fluid structure interaction (FSI) in the presence and absence of ILT may help predict AAA rupture risk better. Two patients, with varied AAA geometries and ILT structures, were studied and compared in detail. The patient specific 3D geometries were reconstructed from CT scans, and uncoupled FSI approach was applied. Complex flow trajectories within the AAA lumen indicated a viable mechanism for the formation and growth of the ILT. The resulting magnitude and location of the peak wall stresses was dependent on the shape of the AAA, and the ILT appeared to reduce wall stresses for both patients. Accordingly, the inclusion of ILT in stress analysis of AAA is of importance and would likely increase the accuracy of predicting AAA risk of rupture.

Keywords: intraluminal thrombus; abdominal aortic aneurysm; FSI modelling; risk of rupture

Document Type: Research article

DOI: 10.1080/10255840802176396

Affiliations: 1: Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, USA 2: Laboratory for Research on Structural Models, Department of Structural Engineering, Ghent University, Ghent, Belgium 3: Department of Surgery, Stony Brook University Hospital, Stony Brook University, Stony Brook, NY, USA 4: Laboratory for Mechanical Construction and Production, Ghent University, Ghent, Belgium 5: IBiTech, Institute Biomedical Technology, Ghent University, Ghent, Belgium

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