IngentaConnect Homogenization for a non-local coupling model

Author: Hochmuth, R.¹

Source: Applicable Analysis, Volume 87, Number 12, December 2008 , pp. 1311-1323(13)

Abstract:

In [P. Deuflhard and R. Hochmuth, On the thermoregulation in the human microvascular system, Proc. Appl. Math. Mech. 3 (2003), pp. 378-379; P. Deuflhard and R. Hochmuth, Multiscale analysis of thermoregulation in the human microsvascular system, Math. Meth. Appl. Sci. 27 (2004), pp. 971-989; R. Hochmuth and P. Deuflhard, Multiscale analysis for the bio-heat transfer equation-the nonisolated case, Math. Models Methods Appl. Sci. 14(11) (2004), pp. 1621-1634], homogenization techniques are applied to derive an anisotropic variant of the bio-heat transfer equation as asymptotic result of boundary value problems providing a microscopic description for microvascular tissue. In view of a future application on treatment planning in hyperthermia, we investigate here the homogenization limit for a coupling model, which takes additionally into account the influence of convective heat transfer in medium-size blood vessels. This leads to second-order elliptic boundary value problems with non-local boundary conditions on parts of the boundary. Moreover, we present asymptotic estimates for first-order correctors.

Keywords: homogenization; non-local boundary conditions; Robin boundary conditions; correctors; heat transfer; bio-heat equation; hyperthermia

Document Type: Research article

DOI: 10.1080/00036810802555433

Affiliations: 1: FB Mathematik, Universitat Kassel, Kassel, Germany

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