New cycloartane glycosides from Camptosorus sibiricus Rupr
Three new cycloartane glycosides were isolated from the whole herbs of Camptosorus sibiricus Rupr. By means of chemical and spectroscopic methods (IR, 1D, and 2D NMR, HR-MS, ESI-MS), the structures were established as (24R)-3,7,24,25, 30-pentahydroxycycloartane-3-O--d-glucopyranosyl-(1 → 4)-[α-l-arabinopyranosyl-(1 → 2)--d-glucopyranosyl]-24-O--d-glucopyranoside (1), (24R)-3,7,24,25,30-pentahydroxycycloartane-3-O--d-glucopyranosyl-(1 → 4)-[-d-galactopyranosyl-(1 → 2)--d-glucopyranosyl]-24-O--d-glucopyranoside (2), (24R)-3,7,24,25,30-pentahydroxycycloartane-30-O-coumaroyl-3-O--d-glucopyranosyl-24-O--d-glucopyranosyl-(1 → 2)--d-glucopyranoside (3). At the same time, the new compounds were tested for their cytotoxicities in vitro against human tumor cell lines (A375-S2, Hela) using MTT method.
Keywords: Camptosorus sibiricus Rupr; cycloartane glycosides; cytotoxicity; triterpenoids
Document Type: Research Article
Affiliations: Institute of Pharmaceutical Informatics, Zhejiang University in Zijingang Campus, Hangzhou, China
Publication date: 01 November 2008
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