Oral treatment with yolk antibodies for the prevention of C. albicans infections in chemotherapy treated children. A feasibility study
Authors: Wilhelmson, Maria1; Carlander, David2; Kreuger, Anders1; Kollberg, Hans1; Larsson, Anders2
Source: Food and Agricultural Immunology, Volume 16, Number 1, March 2005 , pp. 41-45(5)
Publisher: Taylor and Francis Ltd
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Abstract:
Cancer patients treated with chemotherapy often become neutropenic, which predisposes for oral and systemic C. albicans infections. The purpose of this feasibility study was to find out if gargling with anti- C. albicans immunoglobulin Y from egg yolk can prevent oral candidiasis in children, treated for acute lymphatic leukemia. Four patients gargled with the antibodies once a day during the induction phase of chemotherapy. None of four patients treated with IgY got any C. albicans infection. In the non-treated control and in a historic group, seven of thirteen patients had suspected C. albicans infection. This study indicates that anti- C. albicans IgY may prevent oral candidiasis in immunocompromized children.Keywords: Oral immunotherapy; yolk antibodies; C. albicans; children; acute lymphatic leukemia
Document Type: Research article
DOI: 10.1080/09540100400003543
Affiliations: 1: Department of Pediatrics, Clinical Chemistry, University Hospital, Uppsala, Sweden 2: Department of Medical Sciences, Clinical Chemistry, University Hospital, Uppsala, Sweden
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