Skip to main content

Pharmacokinetics of gatifloxacin in broiler chickens following intravenous and oral administration

Buy Article:

$63.00 plus tax (Refund Policy)

Abstract:

1. The pharmacokinetics of gatifloxacin were investigated following intravenous and oral administration of a single dose at a rate of 10 mg/kg body weight in broiler chicks.

2. Drug concentration in plasma was determined using High Performance Liquid Chromatography with ultraviolet detection on samples collected at frequent intervals after drug administration.

3. Following intravenous administration, the drug was rapidly distributed (t1/2α: 0·33 ± 0·008 h) and eliminated (t1/2β: 3·62 ± 0·03 h; ClB: 0·48 ± 0·002 l/h/kg) from the body.

4. After oral administration, the drug was rapidly absorbed (C max: 1·74 ± 0·024 µg/mL; T max: 2 h) and slowly eliminated (t1/2β: 3·81 ± 0·07 h) from the body. The apparent volume of distribution (Vd(area)), total body clearance (ClB) and mean residence time (MRT) were 3·61 ± 0·04 l/kg, 0·66 ± 0·01 l/h/kg and 7·16 ± 0·08 h, respectively. The oral bioavailability of gatifloxacin was 72·96 ± 1·10 %.

5. Oral administration of gatifloxacin at 10 mg/kg is likely to be highly efficacious against susceptible bacteria in broiler chickens.

Document Type: Research Article

DOI: https://doi.org/10.1080/00071668.2012.682724

Affiliations: Department of Veterinary Pharmacology & Toxicology,Veterinary College, Anand Agricultural University, Anand, Gujarat, India

Publication date: 2012-04-01

More about this publication?
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more