Insulin administration suppresses an increase in insulin-like growth factor binding protein-2 gene expression stimulated by fasting in the chicken

Authors: K. Nagao; M. Aman Yaman; A. Murai; T. Sasaki; N. Saito; J. Okumura; K. Kita

Source: British Poultry Science, Volume 42, Number 4, 1 September 2001 , pp. 501-504(4)

Buy & download fulltext article:

Price: $55.77 plus tax (Refund Policy)

Abstract:

1. We examined the changes in plasma IGF-I concentration and tissue IGFBP-2 gene expression of young fasted chickens refed a commercial diet or administered bovine insulin intravenously.

2. Plasma IGF-I concentration was decreased by fasting for 2 d. Although plasma IGF-I concentration was increased by refeeding, it didn't recover to the level of chickens fed a commercial diet ad libitum.

3. Insulin administration lowered plasma IGF-I concentration compared to other groups.

4. Hepatic IGFBP-2 mRNA was increased by fasting for 2 d and decreased by refeeding for 6 h. Insulin administration also decreased hepatic IGFBP-2 gene expression stimulated by fasting to the level of refed chickens.

5. IGFBP-2 mRNA in the gizzard was increased by fasting for 2 d and tended to decrease after refeeding for 6 h. Insulin administration decreased gizzard IGFBP-2 gene expression to less than that in refed chickens.

6. There was no between-treatment difference in IGFBP-2 mRNA in the brain and kidney.

7. These results suggest that the changes in IGFBP-2 gene expression in the liver and gizzard by fasting and refeeding might be partly regulated by the alteration in plasma insulin concentration.

Document Type: Research article

DOI: http://dx.doi.org/10.1080/00071660120070622

Publication date: 2001-09-01

More about this publication?