IngentaConnect In Vitro Penetration of Pig Skin by Heavy Metals in Soil

Authors: ABDEL-RAHMAN, MOHAMED¹; SKOWRONSKI, GLORIA¹; TURKALL, RITA²

Source: Soil and Sediment Contamination (formerly Journal of Soil Contamination), Volume 14, Number 1, 2005 , pp. 123-134(12)

Publisher: Taylor and Francis Ltd

Abstract:

The potential health risk from exposure to heavy metal contaminated soil is often based on the quantity of metal that can be removed from soil by vigorous extraction procedures. This approach can overestimate risk since it ignores complex interactions between metals and soil that can result in a reduction in the amount of metal that desorbs from soil and is subsequently absorbed by the body. The aim of this research was to determine the relative contribution of the soil matrix and heavy metal sequestration in soil with time (“aging”) on the dermal penetration of arsenic, mercury, and nickel, respectively, as arsenic acid, mercuric chloride, and nickel chloride. In vitro flow-through diffusion cell studies were performed utilizing dermatomed male pig skin and radioactive compounds to measure total penetration (the sum of each metal in receptor fluid and skin). For arsenic and nickel, the soil matrix produced a 78–87% reduction in dermal penetration compared to 12–19% after aging. A greater effect was observed with aged mercury (52–56% decrease in dermal penetration) than in freshly spiked soil (40–43%). The results indicate that the potential health risk from dermal exposure to the metals can be significantly reduced by soil and aging.

Keywords: Arsenic; mercury; nickel; dermal contact; matrix effect; aging

Document Type: Research article

DOI: 10.1080/15320380590911742

Affiliations: 1: University of Medicine and Dentistry of New Jersey, Pharmacology and Physiology Department, New Jersey Medical School, Newark New Jersey 2: University of Medicine and Dentistry of New Jersey,Clinical Laboratory Sciences Department, School of Health Related Professions, Newark New Jersey

The full text electronic article is available for purchase. You will be able to download the full text electronic article after payment.

$45.09 plus tax