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Nano-Hydroxyapatite/Chitosan/Konjac Glucomannan Scaffolds Loaded with Cationic Liposomal Vancomycin: Preparation, In Vitro Release and Activity against Staphylococcus aureus Biofilms

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Abstract:

The objective of this study was to design a novel artificial bone scaffold for the therapy and prevention of refractory bacterial infections. Porous nano-hydroxyapatite/chitosan/konjac glucomannan (n-HA/CS/KGM) scaffolds were loaded with cationic liposomal vancomycin (CLV) to form a novel complex drug carrier (LLS). The kinetics of CLV release from LLS and the effects of the amount of konjac glucomannan (KGM) and CLV in LLS were examined in vitro. The anti-biofilm activity of LLS was also studied. Electron microscopy indicated that the liposomes were well preserved in the scaffold, and that CLV rather than free vancomycin is released from the scaffold. The weight percentage of KGM or CLV greatly influenced the release behavior of the scaffolds. LLS could provide sustained CLV release and inhibited the formation of Staphylococcus aureus biofilms better than scaffolds without CLV loaded. LLS may be a novel, effective drug-delivery system for the antibiotic treatment of osteomyelitis caused by biofilm infections.

Keywords: BIOFILMS; CONTROLLED DRUG RELEASE; IN VITRO; LIPOSOMAL VANCOMYCIN; OSTEOMYELITIS; SCAFFOLD

Document Type: Research Article

DOI: https://doi.org/10.1163/092050611X570644

Affiliations: 1: Kunming General Hospital of Chengdu Military Region, 212 Daguanlu Road, Kunming 650032, Yunnan, P. R. China; Third Military Medical University, Chongqing 400037, P. R. China 2: Kunming General Hospital of Chengdu Military Region, 212 Daguanlu Road, Kunming 650032, Yunnan, P. R. China 3: Faculty of Material Science and Engineering, Kunming University of Science and Technology, Kunming 650093, Yunnan, P. R. China 4: Kunming General Hospital of Chengdu Military Region, 212 Daguanlu Road, Kunming 650032, Yunnan, P. R. China., Email: xuyongqingkm@yahoo.c

Publication date: 2011-05-01

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