Synthesis and properties of star oligo/poly(trimethylene carbonate)s with cholic acid moieties as cores
Star oligo/poly(trimethylene carbonate)s with cholic acid moieties as cores were synthesized by ring-opening polymerization of trimethylene carbonate (TMC) initiated by cholic acid with hydroxyl groups. The molecular weights of the star oligomers/polymers were controlled by adjusting
the feed ratio of the initiator cholic acid to the monomer TMC. The star oligo/poly(trimethylene carbonate)s were characterized by Fourier transform infrared spectroscopy (FT-IR), 1H nuclear magnetic resonance spectroscopy (1H-NMR) and combined size-exclusion chromatography
and multiangle laser light scattering (SEC-MALLS) analysis. The water contact angles of the star oligo/poly(trimethylene carbonate)s were measured. Using 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay, the star oligo/poly(trimethylene carbonate) was proved to have
a low cytotoxicity. A microsphere drug-delivery system based on a star polymer was fabricated and its in vitro drug release property was studied.
Keywords: BIODEGRADABLE POLYMERS; FUNCTIONALIZATION; POLYCARBONATES; RING-OPENING POLYMERIZATION
Document Type: Research Article
Affiliations: Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, P. R. China
Publication date: 01 May 2007
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