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Synthetic studies on nonthrombogenic biomaterials 14: synthesis and characterization of poly(ether-urethane) bearing a Zwitterionic structure of phosphorylcholine on the surface

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Abstract:

A new Zwitterionic compound of the phosphorylcholine analogue, 4-hydroxylbutyl phosphorylcholine (HBPC), was synthesized and characterized. HBPC was chemically tethered onto the surface of poly(ether-urethane) (PEU) films with hexamethylene diisocyanate (HDI) as a coupling agent. The existence of a phosphorylcholine structure on the PEU surface was demomstrated by attenuated total reflection Fourier transform infrared spectroscopy (ATR-FT-IR), X-ray photoelectron spectroscopy (XPS) and water contact angle measurements. The nonthrombogenicity of the modified films was evaluated by platelet-rich plasma (PRP) assay. The results showed that films grafted with HBPC have excellent platelet adhesion resistance.

Keywords: NONTHROMBOGENICITY; PHOSPHORYLCHOLINE ANALOGUE; PLATELET ADHESION; POLY(ETHER-URETHANE).; SURFACE CONSTRUCTION; ZWITTERIONIC MOLECULAR STRUCTURE

Document Type: Research Article

DOI: http://dx.doi.org/10.1163/156856203322274950

Publication date: July 1, 2003

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