Characterization of partially saturated poly(propylene fumarate) for orthopaedic application

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Abstract:

A partially saturated linear polyester based on poly(propylene fumarate) (PPF) was synthesized for potential application in filling skeletal defects. The synthesis was carried out according to a two-step reaction scheme. Propylene glycol and fumaryl chloride were first combined to form an intermediate fumaric diester. The intermediate was then subjected to a transesterification to form the PPF-based polymer. This method allowed for production of a polymer with a number average molecular weight up to 1500 and a polydispersity index of 2.8 and below. The polymeric backbone structure was investigated through the use of FTIR and NMR. Kinetic studies of the transesterification allowed mapping of the molecular weight increase with reaction time. The final product was also characterized by thermal and solubility analysis.

Keywords: Poly(propylene fumarate); bone cement; in situ polyrnerizable biomaterials; polymer characterization; unsaturated polymers

Document Type: Research Article

DOI: http://dx.doi.org/10.1163/156856297X00074

Affiliations: 1: Cox Laboratory for Biomedical Engineering, Institute of Biosciences and Bioengineering and Department of Chemical Engineering, Rice University, 6100 S. Main, Houston, TX 77005-1892, USA 2: Department of Orthopaedic Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA 3: Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA 4: Orthopaedic Biomechanics Laboratory, Beth Israel Hospital, Harvard Medical School, Boston, MA 02215, USA 5: Polymer Branch, WL/MLBP, Materials Directorate, Wright Laboratory, 2941 P Street Ste 1, Wright-Patterson AFB, OH 45433-7750, USA 6: Department of Chemistry, MS-60, Rice University, 6100 S. Main, Houston, TX 77005-1892, USA

Publication date: January 1, 1997

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