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Phase transition parameters of potential thermosensitive drug release systems based on polymers of N-alkylmethacrylamides

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Abstract:

The phase separation and its thermohysteresis in dilute aqueous solutions of polymeric components of potential drug release systems (homopolymers and copolymers of N-isopropylacrylamide, N-isopropylmethacrylamide, N-propylmethacrylamide, N-sec-butylmethacrylamide, and N-(2-hydroxypropyl)methacrylamide) was studied, both on heating and cooling. Plots of light transmittance vs temperature were constructed and the parameters characterizing them were correlated with polymer structures. Qualitative information was obtained on the rate of formation of the concentrated phase on heating and its disappearance on cooling. Attention has been drawn to the improper identification of the cloud-point temperature, measured at an arbitrary concentration, with the lower critical solution temperature (LCST) as is frequently found in papers dealing with biomedical applications of thermosensitive polymers.

Keywords: Thermosensitive polymers; cloud-point temperature; lower critical solution temperature; phase separation; poly(N-alkylmethacrylamide); poly(N-isopropylacrylamide); thermohysteresis

Document Type: Research Article

DOI: https://doi.org/10.1163/156856297X00010

Affiliations: Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, 16206 Prague 6, Czech Republic

Publication date: 1997-01-01

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