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Perspectives for biophysicochemical modifications of enzymes

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This article reviews the strategies and successes of modifying enzymes by means of biophysicochemical transformations. By judicious choice of methods, it has been possible to modify enzymes through physical interactions, chemical reactions and/or mutagenesis to alter a very wide range of properties ranging from stability and solubility on the one hand to catalytic activity and selectivity on the other.
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Document Type: Research Article

Affiliations: 1: Departamento de Química Física, Facultad de Farmacia, Apartado 449, Universidad de Salamanca, 37080 Salamanca, Spain 2: Birmingham Carbohydrate and Protein Technology Group, Research Laboratory for the Chemistry of Bioactive Carbohydrates and Proteins, School of Chemistry, Birmingham University, PO Box 363, Birmingham B15 2TT, UK

Publication date: 1996-01-01

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