A model for thromboembolization on biomaterials

$63.37 plus tax (Refund Policy)

Buy Article:

Abstract:

A model was developed to describe the kinetics of protein and platelet deposition and embolization on biomaterials. The model assumes that proteins can be adequately represented by fibrinogen, albumin, and Factor XII, that protein adsorption is Langmuir-type, that surfaces are homogeneous, and that all adsorption and deposition steps are first order. Eleven model parameters were determined from literature experimental data from ex vivo experiments utilizing canine and baboon blood on Silastic, one parameter came from adsorption of Factor XII on glass, and three parameters were obtained by minimizing differences between experimental and predicted fibrinogen adsorption, and platelet deposition and embolization behavior. The model well predicted observed behavior for fibrinogen adsorption, platelet deposition, and platelet embolization on Silastic, and platelet embolization from both polyacrylamide and HEMA-MAAC.

Keywords: Thrombosis; biomaterials; embolization; models; platelets; protein adsorption

Document Type: Research Article

DOI: http://dx.doi.org/10.1163/156856293X00122

Affiliations: Bioengineering Program, University of Illinois at Chicago, Box 4348 (Mail Code 063), Chicago, IL 60680, USA

Publication date: January 1, 1993

Related content

Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more