A series of novel polyisobutylene (PIB)-toughened poly(methyl methacrylate) (PMMA) networks consist of rubbery PIB domains covalently bonded to a glassy PMMA matrix. Materials containing 8.5-17 wt. % PIB (Mn = 18 000 g/mol) in a PMMA matrix (PIB/PMMA) were evaluated to assess
their feasibility as the powder component along with methyl methacrylate (MMA) as the liquid component in a standard powder/liquid bone cement formulation. A standard ISO four-point bend test, commonly used for testing bone cements, was employed to investigate flexural properties. The mixing
time and powder/liquid (P/L) ratio were studied to formulate novel PIB/PMMA cements for optimum toughness. Appropriate formulations led to improved toughness while adequate flexural strength and modulus were maintained. An experimental PIB/PMMA-system exhibited ∼57 MPa flexural strength
and ∼2000 MPa flexural modulus.