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Iron(III) chelating resins II. 3-Hydroxy-4(1H)-pyridinones-Sepharose gels

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3-Hydroxy-4(1H)-pyridinones(HP)-Sepharose gels were prepared to study their iron(III) chelating properties. As ligands, derivatives of 3-hydroxy-4(1H)-pyridinone were coupled to CNBr-activated Sepharose gels. HP-Sepharose gels were obtained with HP densities of 23-28 μmol/ml gel and iron(III) chelating capacities of 19-23 μmol/ml gel at pH 6.8. From preliminary experiments, it was found that with the gels 19-27% iron could be removed from milk. In addition, 74% of iron(III) was removed from 100% iron(III) saturated lactoferrin within 24 h at pH 6.8 in the presence of citrate and a Sepharose gel, onto which 1-(2-aminoethyl)-3-hydroxy-2-methyl-4(1H)-pyridinone had been immobilized as a ligand. The properties of the gels make them potentially useful as water-insoluble iron(III) chelating agents.

Keywords: 3-hydroxy-4(1H)-pyridinone; Iron(III); L-mimosine; Sepharose; chelating resin; lactoferrin; milk

Document Type: Research Article


Affiliations: Department of Chemical Technology, Biomaterials Section, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands

Publication date: January 1, 1993


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