Skip to main content

Iron(III) chelating resins II. 3-Hydroxy-4(1H)-pyridinones-Sepharose gels

Buy Article:

$63.00 plus tax (Refund Policy)


3-Hydroxy-4(1H)-pyridinones(HP)-Sepharose gels were prepared to study their iron(III) chelating properties. As ligands, derivatives of 3-hydroxy-4(1H)-pyridinone were coupled to CNBr-activated Sepharose gels. HP-Sepharose gels were obtained with HP densities of 23-28 μmol/ml gel and iron(III) chelating capacities of 19-23 μmol/ml gel at pH 6.8. From preliminary experiments, it was found that with the gels 19-27% iron could be removed from milk. In addition, 74% of iron(III) was removed from 100% iron(III) saturated lactoferrin within 24 h at pH 6.8 in the presence of citrate and a Sepharose gel, onto which 1-(2-aminoethyl)-3-hydroxy-2-methyl-4(1H)-pyridinone had been immobilized as a ligand. The properties of the gels make them potentially useful as water-insoluble iron(III) chelating agents.

Keywords: 3-hydroxy-4(1H)-pyridinone; Iron(III); L-mimosine; Sepharose; chelating resin; lactoferrin; milk

Document Type: Research Article


Affiliations: Department of Chemical Technology, Biomaterials Section, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands

Publication date: 1993-01-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more