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Biostability and blood-contacting properties of sulfonate grafted polyurethane and Biomer

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Abstract:

Sulfonate-containing polyurethanes were evaluated for in vivo biodegradation using subcutaneously implanted tensile bars. In addition, these anionically charged polyurethanes were evaluated for in vivo activation of human complement C3a and ex vivo platelet deposition in arteriovenouslyshunted canines. The sulfonate derivatized polymers included laboratory synthesized polyurethane and Biomer. Other polymers used for references included IntramedicTM polyethylene, SilasticTM and a poly(ethylene oxide) based polyurethane. The biodegradation results indicated that Biomer and the laboratory sulfonated Biomer (both manufactured with stabilizers), remained mechanically stable, retaining both tensile strength and elasticity after 4 weeks of subcutaneous implantation. The unstabilized polyurethanes (with or without sulfonation), however, showed marked cracking and a loss of mechanical properties after the same period of subcutaneous implantation. Sulfonated polyurethanes depressed human complement C3a activation in plasma, as indicated by decreased levels of anaphylatoxin production. The results of canine ex vivo blood contacting experiments were conducted in both an acute and chronic model and demonstrated decreased platelet deposition and activation for the sulfonated polyurethanes.

Keywords: In vivo biodegradation; acute ex vivo AV-shunting; chronic arteriovenous shunting; complement activation (C3a); fibrinogen deposition; platelet deposition; polyurethanes; sulfonation

Document Type: Research Article

DOI: http://dx.doi.org/10.1163/156856292X00349

Affiliations: Department of Chemical Engineering, The University of Wisconsin, Madison, WI53706, USA

Publication date: January 1, 1993

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