Circadian and seasonal variations of physiological and biochemical determinants of acute myocardial infarction

Authors: Touitou, Yvan; Bogdan, Andre

Source: Biological Rhythm Research, Volume 38, Number 3, June 2007 , pp. 169-179(11)

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Abstract:

Almost all cardiovascular events occur according to a circadian rhythm with a greater frequency in the morning on waking and when resuming activity, the mechanism and precise triggering events for myocardial infarction (MI) are not yet fully known. Multiple biologic functions show a diurnal and/or seasonal variation that may contribute to adverse cardiac outomes. Exogenous factors may also modulates these variations. The MI peak usually occurs between 07:00 and 12:00 h. This timing corresponds to the concurrent increase in platelet aggregability, blood concentration of cortisol, catecholamines, angiotensin II, myocardial oxygen demand and coagulation activity, while fibrinolytic activity is decreased. In this review paper we will point out the biological rhythms of a number of functions involved in acute myocardial infarction e.g. blood pressure, hormonal determinants, cholesterol, among others.

Keywords: Myocardial infarction; circadian rhythm; hormones; melatonin; cortisol; sex hormones

Document Type: Research article

DOI: http://dx.doi.org/10.1080/09291010600906075

Affiliations: 1: Laboratoire de Biochimie Médicale & INSERM U-713, Faculty of Medicine Pierre & Marie Curie - Pitie, Paris, France

Publication date: 2007-06-01