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Do Current Standards of Practice in Canada Measure What is Relevant to Human Exposure at Contaminated Sites? II: Oral Bioaccessibility of Contaminants in Soil

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Human health risk estimates for sites with contaminated soils are often based on the assumption that the outdoor soil sieved to In vitro bioaccessibility tests are also increasingly used to “improve” ingestion exposure predictions of contaminants at different sites. However, when considered in terms of factors that influence desorption of contaminants from particles and uptake into humans, available studies indicate that current “standards of practice” with respect to assays of oral bioaccessibility have a number of significant shortcomings, at least in Canada. These shortcomings are discussed and various factors that influence the assessment of bioaccessibility of contaminants in soils are examined. We finish with proposing some minimum data submission requirements to support the application and relevance of bioaccessibility assays at contaminated sites.

Keywords: bioaccessibility; bioavailability; contaminant; contaminated sites; exposure; risk assessment; soil

Document Type: Research Article


Affiliations: 1: Health Canada, Ottawa, ON, Canada 2: Royal Roads University, Victoria, BC, Canada

Publication date: June 1, 2006


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