Framework for the Integration of Health and Ecological Risk Assessment
The World Health Organization's International Programme on Chemical Safety (IPCS), the Organization for Economic Cooperation and Development (OECD), and the U.S. Environmental Protection Agency have developed a collaborative partnership to foster integration of assessment approaches for human health and ecological risks. This paper presents the framework developed by that group. Integration provides coherent expressions of assessment results, incorporates the interdependence of humans and the environment, uses sentinel organisms, and improves the efficiency and quality of assessments relative to independent human health and ecological risk assessments. The paper describes how integration can occur within each component of risk assessment, and communicates the benefits of integration at each point. The goal of this effort is to promote the use of this internationally accepted guidance as a basis for harmonization of risk assessment.
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Document Type: Research Article
National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, 26 W. Martin L. King Drive, MS-117, Cincinnati, OH 45268, USA.
Toxicology Advisory Centre, National Institute of Public Health and the Environment, The Netherlands.
National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Narraganset, RI, USA.
Division of Information on Chemical Safety, National Institute of Health Science, Tokyo, Japan
Publication date: 2003-01-01