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Assessment of the Dermal Bioavailability of Soil-Aged Benzo( a )pyrene

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Abstract:

Exposure to polycyclic aromatic hydrocarbons (PAHs) in soil is a major health concern because of their mutagenic and carcinogenic properties. The aim of this research was to determine the dermal bioavailability of benzo(a)pyrene (BaP) aged in either a sandy or a clay soil in order to assess the health risks and remediation goals for the chemical. In vitro flow-through diffusion cell studies were conducted utilizing dermatomed male pig skin. The amount of radioactive chemical was measured that penetrated skin into receptor fluid and which was bound to skin following soap and water decontamination. BaP bioavailability was decreased by 95 to 98% after 3 months of aging in soil relative to the pure compound. Less than 0.3% of the dose was detected in receptor fluid for all treatments. While most of the dose was bound to skin after administering the pure compound, the majority of the radioactivity was found in the soil and decontaminate after aging. The results indicate that the health risk from exposure to BaP is significantly reduced as the compound ages in soil and that less soil cleanup would be needed at sites contaminated with aged BaP.

Keywords: PAHs; matrix effects; polyaromatic hydrocarbon; skin penetration

Document Type: Research Article

DOI: http://dx.doi.org/10.1080/20028091056999

Affiliations: 1: University of Medicine and Dentistry of New Jersey, Pharmacology and Physiology Department, New Jersey Medical School, and Clinical Laboratory Sciences Department, School of Health Related Professions, Newark, New Jersey 2: Clinical Laboratory Sciences Department, School of Health Related Professions, Newark, New Jersey

Publication date: April 1, 2002

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