Skip to main content

Assessment of Persistent Organic Pollutant (POP) Bioavailability and Bioaccessibility for Human Health Exposure Assessment: A Critical Review

Buy Article:

$63.00 plus tax (Refund Policy)


Persistent organic pollutants (POPs) are ubiquitous environmental contaminants which persist in the environment, bioaccumulate through the food chain, and pose a risk of causing adverse effects to human health and the environment. When quantifying exposure to POPs via incidental soil ingestion for human health risk assessment, it is assumed that 100% of the contaminant is bioavailable for absorption into systemic circulation. However, this assumption may overestimate exposure thereby influencing risk calculations. A variety of in vivo and in vitro methods have been developed in order to quantify POP bioavailability for exposure assessment. The authors review bioavailability assays utilizing animal models (in vivo), surrogate assays (in vitro) for estimating in vivo POP bioavailability, the validation of surrogate assays, and future research needs for POP bioavailability determination.

Keywords: bioaccessibility; bioavailability; in vitro; in vivo; persistent organic pollutant

Document Type: Research Article


Affiliations: Centre for Environmental Risk Assessment and Remediation (CERAR), University of South Australia and the Cooperative Research Centre for Contamination Assessment and Remediation of the Environment (CRC CARE), Adelaide, Australia

Publication date: 2011-01-01

  • Access Key
  • Free ContentFree content
  • Partial Free ContentPartial Free content
  • New ContentNew content
  • Open Access ContentOpen access content
  • Partial Open Access ContentPartial Open access content
  • Subscribed ContentSubscribed content
  • Partial Subscribed ContentPartial Subscribed content
  • Free Trial ContentFree trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more