Assessment of Persistent Organic Pollutant (POP) Bioavailability and Bioaccessibility for Human Health Exposure Assessment: A Critical Review
Abstract:Persistent organic pollutants (POPs) are ubiquitous environmental contaminants which persist in the environment, bioaccumulate through the food chain, and pose a risk of causing adverse effects to human health and the environment. When quantifying exposure to POPs via incidental soil ingestion for human health risk assessment, it is assumed that 100% of the contaminant is bioavailable for absorption into systemic circulation. However, this assumption may overestimate exposure thereby influencing risk calculations. A variety of in vivo and in vitro methods have been developed in order to quantify POP bioavailability for exposure assessment. The authors review bioavailability assays utilizing animal models (in vivo), surrogate assays (in vitro) for estimating in vivo POP bioavailability, the validation of surrogate assays, and future research needs for POP bioavailability determination.
Document Type: Research Article
Affiliations: Centre for Environmental Risk Assessment and Remediation (CERAR), University of South Australia and the Cooperative Research Centre for Contamination Assessment and Remediation of the Environment (CRC CARE), Adelaide, Australia
Publication date: 2011-01-01