Authors: Jones, Gregory T.; van Rij, A.M.; Hill, G.B.; Wilkins, G.T.; Williams, M.J.A.

Source: Journal for Vascular Ultrasound, Volume 32, Number 3, September 2008 , pp. 129-132(4)

Publisher: Society for Vascular Ultrasound

Abstract:

Introduction. —Coronary artery in-stent restenosis (ISR) consists of a rapid vascular smooth muscle cell proliferation after stent placement. This study tested the hypothesis that carotid artery intimal thickening may be associated with susceptibility to coronary ISR.

Methods. —Coronary stent treated patients with (ISR, n = 81) and without (ISR-free, n = 163) ISR were examined along with age- and gender-matched vascular disease-free controls (n = 200). All participants underwent bilateral carotid duplex ultrasound assessment and cardiovascular risk factor evaluation. Multiple logistic regressions were used to determine the independence of any risk associations with either coronary artery disease or ISR.

Results. —Maximal carotid intimal medial thickness was independently associated with symptomatic coronary ISR, with an adjusted odds ratio of 3.4 (95% confidence interval, 1.5-7.7, p < 0.005 for carotid intimal medial thickness >1 mm). Atherosclerosis within the carotid bifurcation and internal carotid artery, as measured by carotid stenosis scores, was significantly greater in both coronary artery patient groups compared with vascular disease-free controls but was not associated with ISR.

Conclusions. —Intimal thickening within the common carotid artery may represent a distinct pathological process from that which occurs within the carotid bifurcation and internal carotid arteries. Changes in common carotid IMT appears to represent an independent risk indicator for symptomatic coronary ISR.

Document Type: Research article

Publication date: 2008-09-01

More about this publication?

• The Journal for Vascular Ultrasound (JVU) is the official journal of the Society for Vascular Ultrasound. It consists of original scientific and educational articles, case studies, book reviews, technical reviews, ultrasound principle reviews, viewpoints, letters to the editor, and CME tests. Regular reading of JVU, published quarterly, will keep you current in your field and provide essential information that can be applied in your practice.
  
  Previously known as the Journal of Vascular Technology - View Volumes 16-26 here
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• In this Subject: Radiology & Imaging ,  Acoustics
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