Authors: Kemp, Terence J.; McIntyre, Robin A.

Source: Progress in Reaction Kinetics and Mechanism, Volume 32, Number 4, 2007 , pp. 219-229(11)

Publisher: Science Reviews 2000 Ltd

Abstract:

The UV-induced photodegradation of supercoiled DNA in aqueous solution is accelerated in the presence of a suspension of TiO₂ nanoparticles. While nearly all samples of TiO₂ are active in this respect, they differ markedly according to (i) the crystal structure of the TiO₂; (ii) the presence of an external oxide coating on the TiO₂; (iii) the presence within the TiO₂ of dopant transition metal ions. Thus anatase is more active than rutile; coated TiO₂ is less active than uncoated TiO₂; the presence of all transition metal ions except Cr(III) acts to enhance the activity of the TiO₂. Only Cr(III) acts to protect the DNA from enhanced degradation, while Mo(VI) ions render the TiO₂ highly aggressive. The relative behaviour of these modified forms of TiO₂ towards DNA on UV excitation closely parallels that previously found in that towards a number of synthetic polymers. The mechanisms for the varying actions of the pigments are discussed.

Keywords: photodegradation; DNA; Titanium dioxide

Document Type: Research article

DOI: http://dx.doi.org/10.3184/146867807X248711

Affiliations: 1: Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK

Publication date: 2007-11-01

More about this publication?

• Progress in Reaction Kinetics & Mechanism is an international journal for the quarterly publication of both in-depth reviews and research articles.

  In-depth reviews are comprehensive accounts bringing together work from many sources with the aim of providing an article of lasting value that will become established as the reference source in the particular subject. Research articles, on the other hand, normally focus on a relatively new or recently developed field or technique giving a state-of-the-art account of the subject and may well refer to a narrower range of existing work. It covers the fields of kinetics and mechanisms of chemical processes in the gas phase and solution of both simple and complex systems.

• Editorial Board
• Subscribe to this Title
• ingentaconnect is not responsible for the content or availability of external websites

Related content

• In this: publication
• By this: publisher
• In this Subject: Analytical Chemistry ,  Physical & Theoretical Chemistry
• By this author: Kemp, Terence J. ;  McIntyre, Robin A.

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers