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Efficient one-pot three-component reaction for the synthesis of (5-aryl-1,3,4-oxadiazol-2-yl)(pyridin-2-yl)methanol derivatives

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(N-Isocyanimino)triphenylphosphorane, 2-pyridinecarbaldehyde and four halogenated aromatic carboxylic acids undergo a 1 : 1 : 1addition reaction under mild conditions in a one-pot reaction to afford four novel (5-aryl-1,3,4-oxadiazol-2-yl)(pyridin-2-yl)methanol derivatives in good yields.
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Keywords: (N-ISOCYANIMINO)TRIPHENYLPHOSPHORANE; 1,3,4-OXADIAZOLE; 2-PYRIDINECARBALDEHYDE; ONE-POT THREE-COMPONENT REACTIONS

Document Type: Research Article

Publication date: 05 April 2015

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  • The Journal of Chemical Research is a monthly journal which has a broad international authorship and publishes research papers and reviews in all branches of experimental chemistry.

    Established in 1977 as a joint venture by the British, French and German chemical societies it maintains the high standards set by the founding societies. Each paper is independently peer reviewed and only carefully evaluated contributions are accepted.

    Recent papers have described new synthetic methods, new heterocyclic compounds, new natural products, and the inorganic chemistry of metal complexes.

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