Synthesis and antimicrobial activities of pyrano[3,2-c]quinoline, pyrimido [5',4':5,6]pyrano[3,2-c]quinoline and [1,2,4]triazolo[2",3";:1',6']pyrimido [5',4':5,6]pyrano[3,2-c]quinoline derivatives

Author: Mariah, Fatma E.L.

Source: Journal of Chemical Research, Volume 2009, Number 9, September 2009 , pp. 588-592(5)

Publisher: Science Reviews 2000 Ltd

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Abstract:

The synthesis of novel 7-(4-chlorophenyl)-6-hydroxy-3-methoxy-10-methyl-8, 9-dihydro-7 H-pyrimido[5', 4' : 5, 6]pyrano-[3, 2-c]quinoline and [1, 2, 4]triazolo[2", 3" : 1', 6']pyrimido[5', 4' : 5, 6]pyrano[3, 2-c]quinoline derivatives has been reported. The key intermediate 2-amino-4-(4-chlorophenyl)-5-hydroxy-8-methoxy-4H-pyrano[3, 2-c]-quinoline-3-carbonitrile was obtained by treating 4-hydroxy-7-methoxyquinolin-2(1H)-one with various substituted α-cyanocinnamonitrile in ethanolic piperidine solution. Antimicrobial activity was shown for most of the synthesised compounds.

Keywords: α-CYANO-P-CHLOROCINNAMONITRILE; ETHYL α-CYANO-P-CHLOROCINNAMATE; 4-HYDROXY-7-METHOXYQUINOLIN-2(1 H)-ONE; PYRANO [3, 2-C]QUINOLINE; PYRIMIDO[5', 4' : 5, 6]PYRANO[3, 2-C]QUINOLINE; [1, 2, 4]TRIAZOLO[2", 3" : 1', 6']PYRIMIDO[5', 4' : 5, 6]PYRANO[3, 2-C] QUINOLINE

Document Type: Research article

DOI: http://dx.doi.org/10.3184/030823409X12509546260155

Publication date: 2009-09-01

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The Journal of Chemical Research is a monthly journal which has a broad international authorship and publishes research papers and reviews in all branches of experimental chemistry.
Recent papers have described new synthetic methods, new heterocyclic compounds, new natural products, and the inorganic chemistry of metal complexes. Now in its 34th year, the Journal of Chemical Research was established in 1977 as a joint venture by the British, French and German chemical societies and maintains the high standards set by the founding societies. Each paper is independently peer reviewed and only carefully evaluated contributions are accepted.
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Synthesis and antimicrobial activities of pyrano[3,2-c]quinoline, pyrimido [5',4':5,6]pyrano[3,2-c]quinoline and [1,2,4]triazolo[2",3";:1',6']pyrimido [5',4':5,6]pyrano[3,2-c]quinoline derivatives

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