One-pot synthesis of trans-4-alkylthio- and 4-arylthio-cinnamic acids from trans-4-chlorosulfonylcinnamic acid in an aqueous medium

Authors: Zhang, Wensheng; Kuang, Chunxiang; Yang, Qing

Source: Journal of Chemical Research, Volume 2008, Number 9, September 2008 , pp. 546-548(3)

Publisher: Science Reviews 2000 Ltd

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Abstract:

A one-pot syntheses of trans-4-alkylthio- and 4-arylthio-cinnamic acids were achieved in high yields by reduction of trans-4-chlorosulfonylcinnamic acid with stannous chloride dihydrate followed by alkylation and arylation of the resulting trans-4-thiocinnamic acid with various kinds of alkyl and activated aryl halides in an aqueous medium.

Keywords: CINNAMIC ACID; AQUEOUS MEDIUM; ALKYLAYLSULFIDE; DIARYLSULFIDE; TRANS-BETA-ARYLVINYL BROMIDE; 4-CHLOROSULFORYL-CINNAMIE ACID

Document Type: Research article

DOI: http://dx.doi.org/10.3184/030823408X347576

Publication date: 2008-09-01

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