Synthesis of acyclo C-Nucleosides of H₁-antihistaminic 4-substituted [1,2,4]triazolo[4,3-a]quinazolin-5(4H)-ones

Authors: Shawali, Ahmad S.; Hassaneen, Hamdi M.; Shurrab, Nabil K.h.

Source: Journal of Chemical Research, Volume 2008, Number 7, July 2008 , pp. 425-428(4)

Publisher: Science Reviews 2000 Ltd

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Abstract:

Two series of aldose N-(3-substituted-4-oxo-3,4-dihydroquinazolin-2-yl)hydrazones were prepared by the reaction of each of the aldoses with the appropriate 2-hydrazino-3-substituted-quinazolin-4(3H)-ones. Oxidative cyclisation of these aldose hydrazones with ferric chloride in ethanol yielded the title acyclo C-nucleosides.

Keywords: ALDOSES; C-NUCLEOSIDES; 1,5-ELECTROCYCLISATION; NITRILIMINES

Document Type: Research article

DOI: http://dx.doi.org/10.3184/030823408785702463

Publication date: 2008-07-01

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