A facile synthesis and heteroannulation of thiazolopyrimidine and related heterocyclic systems

Author: Aly, Aly A.

Source: Journal of Chemical Research, Volume 2007, Number 9, September 2007 , pp. 552-556(5)

Publisher: Science Reviews 2000 Ltd

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Abstract:

Reaction of pyrimidinylacetic acid 2 with different electrophilic and nucleophilic reagents gave annulated pyrimidine derivatives 3-11, respectively. Compound 3 ([7-(dibenzothien-2-yl)-5-phenyl-2,3-dihydro-5H-thiazolo[3,2-a]-pyrimidin-6-yl]acetic acid) was transformed to pyrimidinylacetyl azide 12, which upon heterocyclisation with active methylene compounds, acidic and basic reagents furnished functionally substituted heteroaromatic compounds 13-21, respectively. The structures of the synthesised derivatives were elucidated by elemental and spectral analyses.

Keywords: POLYCYCLIC PYRIMIDINES, TRIAZOLYLPYRIMIDINES, ACID

Document Type: Research article

DOI: http://dx.doi.org/10.3184/030823407X248621

Publication date: 2007-09-01

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The Journal of Chemical Research is a monthly journal which has a broad international authorship and publishes research papers and reviews in all branches of experimental chemistry.
Recent papers have described new synthetic methods, new heterocyclic compounds, new natural products, and the inorganic chemistry of metal complexes. Now in its 34th year, the Journal of Chemical Research was established in 1977 as a joint venture by the British, French and German chemical societies and maintains the high standards set by the founding societies. Each paper is independently peer reviewed and only carefully evaluated contributions are accepted.
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