A stereoselective total synthesis of cis-(2R,3S)-3-hydroxypipecolic acid

Authors: Phansavath, Phannarath; Haddad, Mansour

Source: Journal of Chemical Research, Volume 2007, Number 5, May 2007 , pp. 313-316(4)

Publisher: Science Reviews 2000 Ltd

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Abstract:

A stereoselective total synthesis of (2R,3S)-3-hydroxypipecolic acid starting from an enantiomerically pure α-amino alcohol is reported. The synthesis involved a regioselective mesylation and subsequent cyclisation as key steps.

Keywords: L-SERINE, AMINO ALCOHOL, HYDROXYPIPECOLIC ACID, PI

Document Type: Research article

DOI: http://dx.doi.org/10.3184/030823407X218020

Publication date: 2007-05-01

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The Journal of Chemical Research is a monthly journal which has a broad international authorship and publishes research papers and reviews in all branches of experimental chemistry.
Recent papers have described new synthetic methods, new heterocyclic compounds, new natural products, and the inorganic chemistry of metal complexes. Now in its 34th year, the Journal of Chemical Research was established in 1977 as a joint venture by the British, French and German chemical societies and maintains the high standards set by the founding societies. Each paper is independently peer reviewed and only carefully evaluated contributions are accepted.
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