Structural revision of 19, 20-epoxycytochalasin D and its cytotoxic activity

Authors: Shi, Lin-Mei; Zhan, Zha-Jun

Source: Journal of Chemical Research, Volume 2007, Number 3, March 2007 , pp. 144-145(2)

Publisher: Science Reviews 2000 Ltd

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Abstract:

The structure of 19(αH), 20(αH)-epoxycytochalasin D from the fungus Xylaria hypoxylon reported by Espada et al.,1 has been revised to 19(βH), 20(αH)-epoxycytochalasin D (1) by spectroscopic methods (1H NMR, 13C NMR, HMQC, HMBC, and NOESY), and single-crystal X-ray diffraction analysis. Cytotoxic activity against tumor cell line was assessed for compounds 1, and found to show potent cytotoxic activity against tumor cell line P-388.

Keywords: Keywords: 19, 20-epoxycytochalasin D, cytotoxic, E

Document Type: Research article

DOI: 10.3184/030823407X196935

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