Structural revision of 19, 20-epoxycytochalasin D and its cytotoxic activity

Authors: Shi, Lin-Mei; Zhan, Zha-Jun

Source: Journal of Chemical Research, Volume 2007, Number 3, March 2007 , pp. 144-145(2)

Publisher: Science Reviews 2000 Ltd

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Abstract:

The structure of 19(αH), 20(αH)-epoxycytochalasin D from the fungus Xylaria hypoxylon reported by Espada et al.,1 has been revised to 19(βH), 20(αH)-epoxycytochalasin D (1) by spectroscopic methods (1H NMR, 13C NMR, HMQC, HMBC, and NOESY), and single-crystal X-ray diffraction analysis. Cytotoxic activity against tumor cell line was assessed for compounds 1, and found to show potent cytotoxic activity against tumor cell line P-388.

Keywords: Keywords: 19, 20-epoxycytochalasin D, cytotoxic, E

Document Type: Research article

DOI: http://dx.doi.org/10.3184/030823407X196935

Publication date: 2007-03-01

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The Journal of Chemical Research is a monthly journal which has a broad international authorship and publishes research papers and reviews in all branches of experimental chemistry.
Recent papers have described new synthetic methods, new heterocyclic compounds, new natural products, and the inorganic chemistry of metal complexes. Now in its 34th year, the Journal of Chemical Research was established in 1977 as a joint venture by the British, French and German chemical societies and maintains the high standards set by the founding societies. Each paper is independently peer reviewed and only carefully evaluated contributions are accepted.
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