A facile solvent-free one-pot three-component Mannich reaction of aldehydes, amines and terminal alkynes catalysed by CuCl2

Authors: Sharifi, Ali; Mirzaei, Mojtaba; Naimi-Jamal, M. Reza

Source: Journal of Chemical Research, Volume 2007, Number 2, February 2007 , pp. 129-132(4)

Publisher: Science Reviews 2000 Ltd

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Abstract:

A solventless Mannich condensation of aldehydes, amines, and terminal alkynes catalysed by 10 mol% of CuCl2 was investigated. The components were simply mixed and heated together under vacuum, without any need of solid-support or solvent. This results in the formation of Mannich products in high yields.

Keywords: MANNICH REACTION, ALDEHYDES, ALKYNES, SOLVENT-FREE

Document Type: Research article

DOI: http://dx.doi.org/10.3184/030823407X191994

Publication date: 2007-02-01

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