Author: Ookawa, Takanori

Source: Avian and Poultry Biology Reviews, Volume 16, Number 4, November 2005 , pp. 167-173(7)

Publisher: Science Reviews 2000 Ltd

Abstract:

Recent evidence obtained from behavioural and electroencephalographic investigations of chickens in which epilepsy was induced neuropharmacologically or genetically, has led to recognition of the facts that epileptic seizures occur in the chicken and that these seizures reveal many similarities between mammalian and avian epilepsy. Anticonvulsive drugs prevent electroencephalographic and motor seizures in epileptic chickens due to intermittent light stimulation, including seizures that are sensitive to clinically useful antiepileptic agents. By using the brain chimera technology, Le Douarin's group demonstrated that the epileptic phenotype can be partially or totally transferred from Fayoumi epileptic (F.Epi) chickens to a normal chick by grafting specific regions of the embryonic brain, and they concluded that the mesencephalon contains the generator of all epileptic manifestations. Findings of the chicken epileptic changes indicate essentially similarity to those of mammals, including man.

Keywords: chicken forebrain; abnormal EEG; convulsant drugs; epileptic mutant; brain chimera

Document Type: Research article

DOI: http://dx.doi.org/10.3184/147020605783437959

Affiliations: 1: Formerly: Department of Physiology, Gifu University School of Medicine, Gifu, Japan

Publication date: 2005-11-30

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