Suitability of Some Additional Parameters in Reproduction Studies in Japanese Quail: Preliminary Experience

Authors: Selzsam, B.; Niemann, L.; Gericke, C.; Chahoud, I.

Source: Avian and Poultry Biology Reviews, Volume 16, Number 1, February 2005 , pp. 41-46(6)

Publisher: Science Reviews 2000 Ltd

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Abstract:

Against the background of ongoing discussions about the proposal for a new OECD guideline for testing reproduction toxicity in birds (OECD, 2000) and about the best-suited test design for an avian two-generation test, the inclusion of additional parameters and methods is widely discussed. In one-generation studies in Japanese quail (Coturnix coturnix japonica), we investigated a number of these new endpoints such as spermatid count, hormone concentrations (estradiol, LH, progesterone, testosterone, T3, T4) and sex distribution in 14-day old chicks. Data on these parameters are presented with particular regard to untreated animals to show the physiological range and their suitability is discussed. The regular determination of spermatid count, serum concentrations of testosterone (both sexes), estradiol (in females only) and sex ratio is recommended as these variables provide promising measurement endpoints.

Keywords: Japanese quail; reproduction; spermatid count; hormones; sex ratio

Document Type: Research article

DOI: http://dx.doi.org/10.3184/147020605783437986

Affiliations: 1: Federal Institute for Risk Assessment, Berlin, Germany

Publication date: 2005-02-01

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