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Expression of matrix metalloproteinases in Marek's disease tumours

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Abstract:

Marek's disease is an important lymphoproliferative neoplasm of chickens, caused by oncogenic strains of herpes virus. Visceral lymphomas and invasion of both central nervous tissues and peripheral nerves by lymphoid cells are common findings. Matrix metalloproteinases (MMPs) are a group of enzymes responsible for extracellular matrix degradation and tumour metastases. The localisations of MMPs in tumour cells were evaluated immunohistochemically. As a result, positive reactions for MMP-9 and MMP-2 enzymes were found in the lymphoid tumour cells. These enzymes may take part in the pathogenesis of Marek's disease causing extracellular matrix degradation and metastasis.

Keywords: IMMUNOHISTOCHEMISTRY; LYMPHOPROLIFERATIVE DISEASE; MAREK'S DISEASE; MATRIX METALLOPROTEINASES

Document Type: Research Article

DOI: http://dx.doi.org/10.3184/175815512X13267015775641

Publication date: June 1, 2012

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  • Avian Biology Research, formerly Avian & Poultry Biology Reviews, has adopted a new and exciting vision for publication of ornithological research in the 21st Century.

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    Editor-in-Chief: Charles Deeming Editors: Tom Pike; Dale Sandercock; Claudia Wascher

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