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Effect of 17ß-trenbolone on male and female reproduction in Japanese quail (Coturnix japonica)

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The anabolic steroid 17ß trenbolone (17ß-TB), a known endocrine disrupting chemical, may influence reproductive functions in avian wildlife. We evaluated the effects of dietary exposure to 17ß-TB at 5 and 20 ppm on reproductive functional endpoints in Japanese quail during and after sexual maturation. In the male, 5 and 20 ppm treatments revealed no differences in body and testes weight, testes histology, plasma testosterone concentrations, or size and weight of the foam glands. However, the onset of foam production was significantly earlier (days of age) in the 20 ppm males. In females, dietary 17ß-TB at 20 ppm caused a reduction in the number of maturing yellow yolk follicles and overall egg production. Plasma testosterone concentrations were reduced compared to controls. Histology of the oviductal sperm storage tubules was normal in all treatments. The number of sperm holes, sites on the perivitelline layer (PVL) where sperm bound and hydrolyzed a path through the PVL, was significantly greater in the 10th egg laid compared to the 1st egg laid in the 20 ppm treatment. Potential effects, albeit transient, on endpoints associated with male maturation warrant further investigation into the sensitivity of these measures in the event of embryonic and/or trans-generational exposure to 17ß-TB.


Document Type: Research Article


Publication date: June 1, 2012

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  • Avian Biology Research, formerly Avian & Poultry Biology Reviews, has adopted a new and exciting vision for publication of ornithological research in the 21st Century.

    This vision is based on two main concepts. First, the topics published by the journal will cover all aspects of ornithology. This will provide a forum for scientists to publish their work in a journal that will have a broad appeal. Second, the scope of the journal will expand to include reports of original research, letters, perspectives, news, diary and book reviews in addition to reviews. By considering a wide range of research fields for publication, Avian Biology Research provides a forum for people working in every field of ornithology.

    Editor-in-Chief: Charles Deeming Editors: Tom Pike; Dale Sandercock; Claudia Wascher

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