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Examination of Japanese quail chicks in one-generation feeding studies for effects of the agrochemicals dimethoate, fentin hydroxide, and vinclozolin on skeletal development

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Abstract:

An established method for evaluation of skeletal anomalies was successfully adapted to Japanese quail (Coturnix coturnix japonica) and performed on 793 untreated 1-day old chicks to develop an historical control database. Incomplete ossification of the pelvic bones and irregular position of the toes were rather frequently observed. Subsequently, 702 chicks from the treatment groups in three one-generation reproduction studies with the pesticides dimethoate, triphenyltin (fentin) hydroxide, and vinclozolin were compared to their respective controls and the whole historical database. Presumed treatment-related effects were confined to a higher number of chicks with incomplete ossification of vertebrae and pelvis when the hens had been administered fentin hydroxide at a dietary level of 30 ppm for up to 6 weeks, corresponding to a mean daily substance intake of 3.1 – 3.9 mg kg–1 body weight (bw). Thus, inclusion of teratological findings as a further endpoint confirmed the previously established NOAEL of 3 ppm (equal to 0.28 – 0.35 mg kg–1 bw y day) based on reproductive effects in this study. No effects on skeletal development were seen with dimethoate and vinclozolin up to the highest dietary concentrations of 70 and 500 ppm, corresponding to estimated mean daily intakes of about 8 or 56 mg kg–1 bw. The suitability of the method for reliable detection of skeletal anomalies was proven. The established method can be considered useful in providing additional information for ecotoxicological risk assessment.

Keywords: DIMETHOATE; FENTIN HYDROXIDE; JAPANESE QUAIL; SKELETAL ANOMALIES; TERATOLOGY; VINCLOZOLIN

Document Type: Research Article

DOI: https://doi.org/10.3184/175815512X13267954660493

Publication date: 2012-02-01

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  • Avian Biology Research provides a forum for the publication of research in every field of ornithology. It covers all aspects of pure and applied ornithology for wild or captive species as well as research that does not readily fit within the publication objectives of other ornithological journals. By considering a wide range of research fields for publication, Avian Biology Research provides a forum for people working in every field of ornithology. The journal also includes sections on avian news, conference diary and book reviews.

    Editor-in-Chief: Charles Deeming Editors: Tom Pike; Dale Sandercock; Claudia Wascher; Colin Butter
    Production Editor: Claire Pike

    Cover image: A male Lesser Kestrel (Falco naumanni) with a bush cricket as prey, returning to the nest to feed its young. Photo by Anastasios Bounas

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