MEDICINAL CHEMISTRY RESEARCH

Synthesis, biological activities, and pharmacokinetics studies of a mutual prodrug of aceclofenac and paracetamol
pp. 1077-1083(7)
Authors: Husain, A.; Ahuja, P.; Shaharyar, M.; Ahmad, A.; Mkhalid, I. A.; Alam, M. M.; Akhter, M.; Zaman, M. S.

Synthesis and antioxidant activity of pyrazolyl-oxazolines/thiazolines and isoxazolyl-oxazolines/thiazolines
pp. 1084-1098(15)
Authors: Padmaja, A.; Rajasekhar, C.; Durgamma, S.; Venkatesh, B. C.; Padmavathi, V.

Antiproliferative effects of novel urea derivatives against human prostate and lung cancer cells; and their inhibition of β-glucuronidase activity
pp. 1099-1113(15)
Authors: Perveen, S.; Mustafa, S.; Qamar, K.; Dar, A.; Khan, K. M.; Choudhary, M. I.; Khan, A.; Voelter, W.

Prospective atom-based 3D-QSAR model prediction, pharmacophore generation, and molecular docking study of carbamate derivatives as dual inhibitors of AChE and MAO-B for Alzheimer’s disease
pp. 1114-1122(9)
Authors: Kumar, V.; Chadha, N.; Tiwari, A. K.; Sehgal, N.; Mishra, A. K.

Synthesis, characterization, biological activity, and 3D-QSAR studies on some novel class of pyrrole derivatives as antitubercular agents
pp. 1123-1147(25)
Authors: Joshi, S. D.; More, U. A.; Dixit, S. R.; Korat, H. H.; Aminabhavi, T. M.; Badiger, A. M.

Quantitative structure–property relationship study on the intercalation of anticancer drugs with ct-DNA
pp. 1148-1161(14)
Authors: Ahmadi, S.; Khazaei, M. R.; Abdolmaleki, A.

Docking and receptor-based QSAR approaches for modeling of CETP inhibitors
pp. 1162-1169(8)
Author: Asadollahi-Baboli, M.

Oligoamides of 2-amino-5-alkylthiazole 4-carboxylic acids: anti-trypanosomal compounds
pp. 1170-1179(10)
Authors: Lang, S.; Khalaf, A. I.; Breen, D.; Huggan, J. K.; Clements, C. J.; MacKay, S. P.; Suckling, C. J.

Synthesis of pyranochromene and pyranopyrimidine derivatives from substituted natural coumarin isolated from Ammi majus L. and their biological evaluation
pp. 1180-1188(9)
Authors: Ouf, N. H.; Selim, Y. A.; Sakran, M. I.; Badr El-din, A. S.

Homology modeling, binding site identification, and docking study of human β-arrestin: an adaptor protein involved in apoptosis
pp. 1189-1201(13)
Authors: Chintha, C.; Gupta, N.; Ghate, M.; Vyas, V. K.

Biotransformation of artemisinin derivatives by Glycyrrhiza glabra, Lavandula officinalis, and Panax quinquefolium
pp. 1202-1206(5)
Authors: Gaur, R.; Patel, S.; Verma, R. K.; Mathur, A.; Bhakuni, R. S.

Regioselective synthesis and antibacterial evaluation of novel bis-pyrimidine derivatives via a three-component reaction
pp. 1207-1213(7)
Authors: Mahmoodi, N. O.; Shoja, S.; Sharifzadeh, B.; Rassa, M.

Synthesis, in vitro antiplasmodial and antiproliferative activities of a series of quinoline–ferrocene hybrids
pp. 1214-1224(11)
Authors: N’Da, D. D.; Smith, P. J.

Cytotoxic activity assessment and c-Src tyrosine kinase docking simulation of thieno[2,3-b] pyridine-based derivatives
pp. 1225-1233(9)
Authors: Nikkhoo, A. R.; Miri, R.; Arianpour, N.; Firuzi, O.; Ebadi, A.; Salarian, A. A.

Rapid in silico selection of an MCHR1 antagonists’ focused library from multi-million compounds’ repositories: biological evaluation
pp. 1234-1247(14)
Authors: Flachner, B. t.; Tömöri, T. n.; Hajdú, I. n.; Dobi, K.; Lőrincz, Z.; Cseh, S. n.; Dormán, G. r.

Novel derivatives of 5-amino-1-cyclopropyl-7-[(3R,5S)3,5-dimethylpiperazine-1-yl]-6,8-difluoro-4-oxo-quinoline-3-carboxylic acid: their synthesis, antimicrobial, antifungal, and urease inhibitory studies
pp. 1248-1256(9)
Authors: Arayne, M. S.; Sultana, N.; Gul, S.; Khan, A.

Synthesis and cytotoxic evaluation of novel 2,3-di-O-alkyl derivatives of l-ascorbic acid
pp. 1257-1266(10)
Authors: Kote, S. R.; Mishra, R.; Khan, A. A.; Thopate, S. R.

Synthesis of hydrophobic N-acylated isonicotinic acid hydrazide derivatives as potential enoyl–acyl carrier protein reductase (InhA) inhibitors
pp. 1267-1277(11)
Authors: Naveen Kumar, H. S.; Parumasivam, T.; Ibrahim, P.; Asmawi, M. Z.; Sadikun, A.

Synthesis and antiproliferative activities of some pyrazole-sulfonamide derivatives
pp. 1278-1289(12)
Authors: Mert, S.; Yağlıoğlu, A. e.; Demirtas, I.; Kasımoğulları, R.

Synthesis and evaluation of novel benzimidazole derivatives as antimicrobial agents
pp. 1290-1299(10)
Authors: Joshi, D.; Parikh, K.

Comparative molecular docking studies of novel 3, 5-disubstituted thiazolidinedione analogs as HIV-1-RT inhibitors
pp. 1300-1308(9)
Authors: Bahare, R. S.; Ganguly, S.

Synthesis of novel pyrazolobenzothiazine 5,5-dioxide derivatives as potent anti-HIV-1 agents
pp. 1309-1319(11)
Authors: Ahmad, M.; Aslam, S.; Bukhari, M. H.; Montero, C.; Detorio, M.; Parvez, M.; Schinazi, R. F.

Synthesis of some benzoxazinyl pyrazolone arylidenes as potent antimicrobials and antioxidants
pp. 1320-1326(7)
Authors: Sonia, G.; Thachil, K. K.; Parameswaran, M. K.; Kochupappy, R. T.

Interactions of G-quadruplex DNA binding site with berberine derivatives and construct a structure-based QSAR using docking descriptors
pp. 1327-1339(13)
Authors: Ebrahimi, M.; Khayamian, T.

Synthesis and antitumor activity evaluation of 2-arylisoquinoline-1,3(2H,4H)-diones in vitro and in vivo
pp. 1340-1349(10)
Authors: Kang, B. R.; Wang, J.; Li, H.; Li, Y.; Mei, Q. B.; Zhang, S. Q.

Synthesis and in vitro antimicrobial evaluation of novel fluorine-containing 3-benzofuran-2-yl-5-phenyl-4,5-dihydro-1H-pyrazoles and 3-benzofuran-2-yl-5-phenyl-4,5-dihydro-isoxazoles
pp. 1350-1359(10)
Authors: Chundawat, T. S.; Sharma, N.; Bhagat, S.

New 4-thiazolidinones from 5-ethyl pyridine-2-ethanol: their antibacterial, antifungal, and antitubercular activity
pp. 1360-1370(11)
Authors: Patel, N. B.; Patel, H. R.; Shaikh, F. M.; Rajani, D.

Synthesis and antibacterial evaluation of 3,3′-diindolylmethane derivatives
pp. 1371-1377(7)
Authors: Roy, S.; Gajbhiye, R.; Mandal, M.; Pal, C.; Meyyapan, A.; Mukherjee, J.; Jaisankar, P.

Synthesis and leishmanicidal activity of cinnamic acid esters: structure–activity relationship
pp. 1378-1386(9)
Authors: Otero, E.; Robledo, S. M.; Díaz, S.; Carda, M.; Muñoz, D.; Paños, J.; Vélez, I. D.; Cardona, W.

Synthesis and biological evaluation of pyrrole-2-carboxamide derivatives: oroidin analogues
pp. 1387-1396(10)
Authors: Takale, B. S.; Desai, N. V.; Siddiki, A. A.; Chaudhari, H. K.; Telvekar, V. N.

Exploring QSAR studies on 4-substituted quinazoline derivatives as antimalarial compounds for the development of predictive models
pp. 1397-1405(9)
Authors: Mishra, M.; Mishra, V. K.; Senger, P.; Pathak, A. K.; Kashaw, S. K.

Novel cyclotides from Hedyotis biflora inhibit proliferation and migration of pancreatic cancer cell in vitro and in vivo
pp. 1406-1413(8)
Authors: Ding, X.; Bai, D.; Qian, J.

A combined approach based on 3D pharmacophore and docking for identification of new aurora A kinase inhibitors
pp. 1414-1436(23)
Authors: Joshi, A. J.; Gadhwal, M. K.; Joshi, U. J.

Synthesis and antitumor activity evaluation of anilinoquinoline derivatives by the effect on the expression of polo-like kinase
pp. 1437-1446(10)
Authors: Peng, H. K.; Lin, I. L.; Lee, C. C.; Wang, L. Y.; Tzeng, C. C.; Chang, J. G.; Yang, S. C.

2D, 3D-QSAR, and pharmacophore studies on thiazolidine-4-carboxylic acid derivatives as neuraminidase inhibitors in H3N2 influenza virus
pp. 1447-1453(7)
Authors: Frimayanti, N.; Lee, V. S.; Zain, S. M.; Wahab, H. A.; Abd. Rahman, N.

p-Toluenesulfonic acid-catalyzed solvent-free synthesis and biological evaluation of new 1-(4′,6′-dimethylpyrimidin-2′-yl)-5-amino-4H-3-arylpyrazole derivatives
pp. 1454-1464(11)
Authors: Aggarwal, R.; Bansal, A.; Rozas, I.; Diez-Cecilia, E.; Kaur, A.; Mahajan, R.; Sharma, J.

Synthesis, cytotoxic evaluation, and molecular docking study of 4,5-diaryl-thiazole-2-thione analogs of combretastatin A-4 as microtubule-binding agents
pp. 1465-1473(9)
Authors: Salehi, M.; Ostad, S. N.; Riazi, G. H.; Assadieskandar, A.; Cheraghi-Shavi, T.; Shafiee, A.; Amini, M.

Synthesis and characterization of novel benzimidazole bearing pyrazoline derivatives as potential antimicrobial agents
pp. 1474-1487(14)
Authors: Desai, N. C.; Pandya, D. D.; Kotadiya, G. M.; Desai, P.

Amberlite IRA 402(OH)-mediated synthesis and evaluation of fused tricyclic quinolinium salts as potent non-detergent type microbicidal spermicides
pp. 1488-1500(13)
Authors: Banerjee, M.; Kumar, S.; Ghosh, S.; Paira, R.; Mondal, S.; Karmokar, S.; Chattopadhyay, D.; Bhadra, R. K.; Mondal, N. B.

Design, synthesis, and antiviral activity of new 1H-1,2,3-triazole nucleoside ribavirin analogs
pp. 1501-1511(11)
Authors: Lourdes G. Ferreira, M.; Pinheiro, L. C.; Santos-Filho, O. A.; Peçanha, M. D.; Sacramento, C. Q.; Machado, V.; Ferreira, V. F.; Souza, T. M.; Boechat, N. b.

Hologram quantative structure–activity relationship studies on 1-(5-carboxyindol-1-yl)propan-2-one inhibitors of human cytosolic phospholipase A2α
pp. 1512-1518(7)
Authors: Yang, X. L.; Zhou, Y.; Liu, X. L.

Synthesis and structure evaluation of new complex butylarylpiperazin-1-yl derivatives
pp. 1519-1536(18)
Authors: Szulczyk, D.; Bielenica, A.; Dobrowolski, M. A.; Dobrzycki, u.; Krawiecka, M.; Kuran, B. e.; Struga, M.

Synthesis, antibacterial screening, and POM analyses of novel bis-isoxazolyl/pyrazolyl-1,3-diols
pp. 1537-1547(11)
Authors: Juneja, H.; Panchbhai, D.; Sheikh, J.; Ingle, V.; Hadda, T. B.

Computer-assisted design of dual-target anti-HIV-1 compounds
pp. 1548-1558(11)
Authors: Guimarães, M. C.; Silva, D. G.; Mota, E. G.; Cunha, E. F.; Freitas, M. P.

Design, synthesis, and antimicrobial activity of some novel homodrimane sesquiterpenoids with diazine skeleton
pp. 1559-1568(10)
Authors: Kuchkova, K.; Aricu, A.; Secara, E.; Barba, A.; Vlad, P.; Ungur, N.; Tuchilus, C.; Shova, S.; Zbancioc, G.; Mangalagiu, I. I.

Eco-friendly synthesis and antimicrobial activities of substituted-5-(1H-indol-3-yl)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione derivatives
pp. 1569-1580(12)
Authors: Thirupathi, G.; Venkatanarayana, M.; Dubey, P. K.; Bharathi Kumari, Y.

Theoretical studies, synthesis, and biological activity of 1-[(4-methylphenyl)sulfonyl]-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine-4-carbonitrile (C9) as a non-peptide antagonist of the arginine vasopressin V1a and V2 receptors
pp. 1581-1590(10)
Authors: Contreras-Romo, M. C.; Correa-Basurto, J.; Padilla-Martínez, I.; Martínez-Archundia, M.; Martínez-Ramos, F.; Ślusarz, M. J.; López-Pérez, G.; Quintanar-Stephano, A. s.

Synthesis and pharmacological evaluation of pyrazolopyrimidopyrimidine derivatives: anti-inflammatory agents with gastroprotective effect in rats
pp. 1591-1598(8)
Authors: Karoui, A.; Allouche, F.; Deghrigue, M.; Agrebi, A.; Bouraoui, A.; Chabchoub, F.

Synthesis and cytotoxic activity of novel hybrid compounds between 2-alkylbenzofuran and imidazole
pp. 1599-1611(13)
Authors: Wan, W. C.; Chen, W.; Liu, L. X.; Li, Y.; Yang, L. J.; Deng, X. Y.; Zhang, H. B.; Yang, X. D.

Synthesis, antimicrobial, and cytotoxicity studies of novel sulfur-linked quinoline–coumarin bisheterocycles
pp. 1612-1621(10)
Authors: Paul, N.; Muthusubramanian, S.