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Home / Spectroscopy and Spectral Analysis, Volume 33, Number 4

Photometric Determination of Captopril Usinglabel-Free Silver Nanoparticles

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A simple, rapid and sensitive colorimetric method for the determination of captopril is presented in the present paper. It is based on the fact that captopril can induce the aggregation of AgNPs, thereby resulting in their yellow-to-red color change and the absorbance decrease at : 395 nm. The mechanism of the aggregation effect was discussed in detail. Under the optimized conditions, the linear range of determination of captopril was 1~35 :g:mL-1 with correction coefficient 0.998 4. The detection limit of the method for captopril was 0.7 :g:mL-1. The method has been applied to the determination of captopril in tablets with satisfactory result.

Keywords: Absorption determination; Captopril; Effect of aggregation; Silver nanoparticles

Document Type: Research Article

Publication date: 15 April 2013

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  • Spectroscopy and Spectral Analysis, founded in 1981, is sponsored by the Chinese Central Iron & Steel Research Institute. "Spectroscopy and Spectral Analysis" has been indexed in SCI(1999), Ei(1992), MEDLINE(1999), and AJ (1999). "Spectroscopy and Spectral Analysis" publishes original contributions on various fields in Spectroscopy, including research results on laser spectroscopy, IR, Ramn, UV/Vis, Optical Emission, Absorption and Fluorescence spectroscopy, X-ray Fluorescence, and Spectrochemical Analysis, as well as Reseach paper, Research notes, Experimental Technique and Instrument, Review and Progress on the latest development of spectroscopy and spectrochemical anlysis, etc. "Spectroscopy and Spectral Analysis" is published monthly by Peking University Press with book sizes of large 16-mo format , and 292 pages per issue.
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